Eén van de meest voorkomende en ernstige complicatie van een hydrocephalusbehandeling is een infectie van de shunt, [1] die 7-15% van de hydrocephaluspatiënten treft. [3] Bij pediatrische als volwassen patiënten kan een shuntinfectie voorkomen en tast hun levenskwaliteit, cognitieve functie en shuntoverleving aan. [2] Shuntinfecties vereisen meestal verwijdering van de shunt, behandeling met antibiotica en opnieuw implanteren. [2] Het gebruik van antibiotica geïmpregneerde katheters kan tweederde van de shuntinfecties voorkomen [4] en helpt zo de belasting voor de patiënt te verminderen en het resultaat te verbeteren.
XABO® ventriculaire en peritoneale katheters zijn geïmpregneerd met antibiotica en geven na implantatie gedurende 38 dagen een effectieve dosis af om shuntinfecties te voorkomen. [5] De uitgebalanceerde verhouding van clindamycinehydrochloride (0,15%) en rifampicine (0,054%) biedt een effectieve bestrijding tegen grampositieve bacteriën. [6] Deze impregnering maakt het mogelijk om een continue lage doses antibiotica vrij te geven, wat allergische reacties voorkomt en het risico op resistentieontwikkeling minimaliseert.
De initiële antibioticalading van XABO® blijft optimaal behouden dankzij het milde e-beam sterilisatieproces en de geavanceerde verpakking. [7] De katheter kan tot 36 maanden worden bewaard en is bestand tegen temperaturen tot 30°C zonder effectiviteit te verliezen. [8]
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